Research

Cancer Imaging

Pancreatic cancer imaging example.

95% of patients with pancreatic cancer die within 5 years of diagnosis. Surgical resection is currently the only treatment option, but only 20% of patients qualify for this surgery. Neoadjuvant chemotherapy can enable patients with borderline resectable tumors to qualify for surgery, but features of the tumor microenvironment (tissue pressure, stromal density, and hyaluronic acid) can reduce its effectiveness. Targeted therapy can mitigate these issues; therefore, the goal of this project is to develop novel surrogate imaging biomarkers for monitoring the effectiveness of neoadjuvant therapies. We use novel imaging techniques to characterize the tumor microenvironment.

Journal Articles

  1. Merging single-track location elastographic imaging with the frequency shift method improves shear wave attenuation measurements
    R. Mislati, K. T. Iliza, S. A. Gerber, and M. M. Doyley
    Front Phys 12 , pp. 1326770-1 -1326770-15  (2024).
  2. Shear wave elastography can stratify rectal cancer response to short-course radiation therapy
    R. Mislati, T. Uccello, Z. Lin, K. T. Iliza, K. C. Toussaint, S. A. Gerber, and M. M. Doyley
    Sci Rep 13(1) , pp. 16149-1 -16149-12  (2023).
  3. Mapping estimates of vascular permeability with a clinical indocyanine green fluorescence imaging system in experimental pancreatic adenocarcinoma tumors
    M. S. Reed, M. Ochoa, K. M. Tichauer, A. Weichmann, M. M. Doyley, and B. W. Pogue
    J Biomed Opt 28(7) , pp. 076001-1 -076001-14  (2023).
  4. H-scan, shear wave, and bioluminescent assessment of the progression of pancreatic cancer metastases in the liver
    J. Baek, R. Ahmed, J. Ye, S. A. Gerber, K. J. Parker, and M. M. Doyley
    Ultrasound Med Biol 46(12) , pp. 3369 -3378  (2020).
  5. Parallel receive beamforming improves the performance of focused transmit based single track location shear wave elastography
    R. Ahmed and M. M. Doyley
    IEEE Trans Ultrason Ferroelectr Freq Control 67(10) , pp. 2057 -2068  (2020).
  6. Preclinical imaging using single track location shear wave elastography: monitoring the progression of murine pancreatic tumor liver metastasis in vivo
    R. Ahmed, J. Ye, S. A. Gerber, D. Linehan, and M. M. Doyley
    IEEE Trans Med Imaging 39(7) , pp. 2426 -2439  (2020).
  7. Shear wave elastography can differentiate between radiation-responsive and non-responsive pancreatic tumors: an ex vivo study with murine models
    H. Wang, B. Mills, R. Mislati, R. Ahmed, S. A. Gerber, D. Linehan, and M. M. Doyley
    Ultrasound Med Biol 46(2) , pp. 393 -404  (2020).
  8. Elastography can map the local inverse relationship between shear modulus and drug delivery within the pancreatic ductal adenocarcinoma microenvironment
    H. Wang, R. Mislati, R. Ahmed, P. Vincent, S. F. Nwabunwanne, J. Gunn, B. W. Pogue, and M. M. Doyley
    Clin Cancer Res 25(7) , pp. 2136 -2143  (2019).
  9. Elastographic assessment of xenograft pancreatic tumors
    H. Wang, M. D. Nieskoski, K. Marra, J. Gunn, B. S. Trembly, B. W. Pogue, and M. M. Doyley
    Ultrasound Med BIol 43(12) , pp. 2891 -2903  (2017).
  10. Collagen complexity spatially defines micro regions of total tissue pressure in pancreatic cancer
    M. D. Nieskoski, K. Marra, J. Gunn, P. J. Hoopes, M. M. Doyley, T. Hasan, B. S. Trembly, and B. W. Pogue
    Sci Rep 7 , pp. 10093-1 -10093-12  (2017).
  11. Separation of solid stress from interstitial fluid pressure in pancreas cancer correlates with collagen area fraction
    M. D. Nieskoski, K. Marra, J. Gunn, S. C. Kanick, M. M. Doyley, T. Hasan, S. P. Pereira, B. S. Trembly, and B. W. Pogue
    J Biomech Eng 139(6) , pp. 061002-1 -061002-8  (2017).
  12. Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressure.
    S. Torosean, B. Flynn, J. Axelsson, J. Gunn, K. S. Samkoe, T. Hasan, M. M. Doyley, and B. W. Pogue
    Nanomedicine. [Epub ahead of print]. (2012).
  13. Interstitial fluid pressure in soft tissue as a result of an externally applied contact pressure.
    A. L. Darling, P. K. Yalavarthy, M. M. Doyley, Hamid Dehghani, and B. W. Pogue
    Phys Med Biol. 52(14). Epub 2007 Jun 13. , pp. 4121 -4136  (2007).